Another way to block skype, please read Blocking Skype with Active Wall Professional.
Skype will readily leak out of the network, using high-numbered ports—either TCP or UDP. As a last resort, it will use ports 80 and 443, which are most commonly used for Web traffic.
1. P2P Filter config
Skype using p2p technology. We should deny p2p connection in p2p filter.
